Hyaluronic Acid Serum in the "taff" Test: High-Dose Hyaluronic Acid with Peptides to Fight Wrinkles

For skin that needs a combination of intense hydration and targeted anti-aging care. It’s particularly beneficial for dry skin, lackluster skin, fine lines caused by dryness, loss of firmness, and increasingly visible wrinkles on the forehead, around the eyes, between the eyebrows, or around the mouth. The lightweight, non-comedogenic texture is suitable for all skin types.

A classic hyaluronic acid serum focuses primarily on hydration. A peptide serum uses short amino acid chains as cosmetic signaling molecules. The Hyper Hyaluron Serum combines both approaches: multiple forms of hyaluronic acid for hydration, plus Argireline™ and SYN®-AKE as neuropeptides that target expression lines.

One of the best-known cosmetic neuropeptides is acetyl hexapeptide-8, known as Argireline™. SYN®-AKE also belongs to this group of active ingredients. Such peptides cannot replace botulinum toxin injections. They are applied topically and used in cosmetics to help promote a smoother and more relaxed-looking complexion. Botox-like peptides are very well tolerated and can also be used during pregnancy and while breastfeeding.

A topically applied peptide serum cannot replace injected Botox on a one-to-one basis—and that is not its intended purpose anyway. Botox is injected directly into the muscle, while a peptide serum is applied externally to the skin, where it improves skin quality and addresses the appearance of lines and wrinkles.

Rather, the Doc Berger Effect Peptide Serum is a non-invasive cosmetic alternative for people who consciously choose to avoid injections or surgical procedures, want to age naturally, and wish to look as fresh and well-groomed as possible.

At the same time, it is a useful addition for those undergoing aesthetic treatments: Even those who use Botox benefit from a consistent peptide skincare regimen that specifically improves skin quality, hydration, and texture—aspects that Botox alone cannot address.

Thus, the serum is not a “substitute” for Botox, but rather—depending on your personal approach—a gentle alternative or a holistic complement.

Because not everyone wants injections—and skincare and Botox serve different purposes. Botox can specifically reduce muscle activity, but it doesn’t automatically improve skin texture, hydration, or skin quality. Additionally, there are areas that aren’t suitable for treatment with Botox (e.g., the delicate under-eye area). This is exactly where effective active-ingredient skincare comes in: The Hyper Hyaluron Serum works topically on the skin and combines intense hydration with two neuropeptides to combat expression lines. This makes it appealing both for people who consciously choose to avoid injections and as a daily complement to professional Botox treatments.

It’s not just about the hyaluronic acid content. A comprehensive hyaluronic acid serum test takes into account molecular sizes, the overall formulation, additional active ingredients, how the product feels on the skin, skin compatibility, before-and-after photos, and skin analysis measurements. In the Taff peptide serum test, an external dermatologist took precisely these aspects into account. Dr. Berger’s peptide serum clearly stood out as the test winner in the “peptides for wrinkles” category.

The Hyper Hyaluron Serum by DOC BERGER EFFECT was independently tested and featured on the TV show “taff” as a hyaluronic acid and peptide serum. Anyone looking to find the serum afterward often searches for combinations of the show’s name, DOC BERGER EFFECT, hyaluronic acid, and peptides. On this page, you’ll find the test context, active ingredient rationale, test results, and application instructions all in one place—so you can quickly get your hands on the test winner before this sought-after serum sells out.

In the PRIMOS instrumental measurement, an average 6% reduction in wrinkle depth was recorded just 15 minutes after a single application. With twice-daily use, the average reduction after 28 days was 17%. The long-term measurement was taken 8 to 12 hours after the last application. Results may vary from person to person.

Yes. We recommend using it especially in the morning after cleansing and toning. If needed, it can also be used in the evening. Thanks to its light texture, it combines well with other serums and the moisturizer you apply afterward. In the morning, for example, mix it 1:1 with the Vitamin C + Spilanthol Serum—for double the anti-wrinkle power and targeted care for dark spots. In the evening, after applying the Hyper Hyaluron Serum, apply the appropriate retinol from DOC BERGER EFFECT to support collagen production and refine the appearance of enlarged pores.

That depends on your individual use. If you only use the serum on your face and need just a few drops, one bottle usually lasts about 3 months. If you also apply it to your neck, décolletage, and hands, or use more product, it will last a correspondingly shorter time.

One bottle usually lasts about 2–4 months. Feel free to apply it generously: your neck, décolletage, and hands benefit just as much from the highly concentrated hyaluronic acid and peptide treatment as your face does.

Yes. The Hyper Hyaluron Serum can be combined with other serums—for example, with the Vit C + Spilanthol Serum in the morning. This serum contains a whopping 20% high-potency premium vitamin C, paired with the plant-based “Botox” ingredient “Spilanthol.” Afterward, you should use a daytime moisturizer with sun protection throughout the day.

In the beauty context, “hyaluron” is usually used as a shortened term for hyaluronic acid or its salts, such as sodium hyaluronate. Search terms like “hyaluron serum,” “hyaluronic acid serum,” “hyaluronic serum,” and “hyaluron booster” therefore often describe very similar product categories.

Anyone looking for the best hyaluronic serum, the best hyaluronic acid serum, or the best peptide serum will find an enormous selection—and price ranges from under 20 euros to several hundred or even over 1,000 euros. But is expensive really better—and how can you tell if a hyaluronic serum is good?

The TV show “taff” (ProSieben) conducted an independent investigation into this very question and had two products from different price points tested in a direct comparison: an affordable peptide serum from a drugstore and the premium hyaluronic acid-peptide serum from DOC BERGER EFFECT, developed by plastic and aesthetic surgeon Dr. Luise Berger of Munich.

After all, what matters for a truly effective hyaluronic acid serum isn’t just how much hyaluronic acid it contains. The key lies in the overall formulation: different forms of hyaluronic acid, thoughtfully combined active ingredients and Botox-like peptides, skin compatibility, and—above all—the question of what the finished product can actually do for the skin. With DOC BERGER EFFECT, as the name suggests, the EFFECT takes center stage.

The Hyper Hyaluron Serum is therefore not merely a hydration booster, but a highly concentrated hyaluronic acid and peptide serum with an anti-aging focus, the effectiveness of which was tested not only in the “Taff Peptide Test” on television but also through external instrumental analysis of the final formulation.