Syn®-Ake: Why “Snake Venom” Helps Fight Wrinkles

How Does Syn®-Ake Affect the Skin?

Syn®-Ake works by blocking specific receptors responsible for transmitting nerve impulses to the facial muscles. This results in a subtle relaxation of the muscles—similar to the effects of botulinum toxin (Botox), but without injections and without diminishing natural facial expressions.

It is therefore not a paralyzing agent, but a precisely dosed relaxation mechanism at the cellular level.

This refined effect offers a key advantage: wrinkle formation is slowed at its origin—within the facial muscle activity itself. The skin can smooth out gently, fine lines appear diminished, and the overall complexion looks fresher and more revitalized. Syn®-Ake delivers especially impressive results in the forehead and eye area, where facial muscles are particularly active.

Its efficacy is supported not only by theoretical research but also by clinical studies. Research (Anti-aging activity of Syn-Ake peptide by in silico approaches and in vitro tests) has shown that after just 28 days of consistent use, wrinkle depth can be visibly reduced by up to 52%. These findings are particularly relevant for expression lines—those caused by repeated muscle movements such as frowning or smiling.

What makes these studies especially compelling is that the concentrations tested align with those commonly used in advanced cosmetic formulations. This means the benefits are not limited to laboratory settings—they are realistically achievable in daily skincare, provided the product is used consistently and correctly.

Reference: Gok B, Budama-Kilinc Y, Kecel-Gunduz S. Anti-aging activity of Syn-Ake peptide by in silico approaches and in vitro tests. J Biomol Struct Dyn. 2024 Jul;42(10):5015-5029. doi:10.1080/07391102.2023.2223681.

5 Key Benefits of Syn®-Ake in Advanced Skincare

1. Targeted Wrinkle Reduction

Syn®-Ake acts like a “gentle muscle relaxant,” specifically inhibiting micro-contractions in the skin that cause forehead lines, frown lines, and crow’s feet.

2. Anti-Aging Alternative to Botox

For those who want results without injections, Syn®-Ake offers the perfect solution. This peptide formula delivers a Botox-like effect—topical, gentle, and highly effective.

3. Exceptional Skin Compatibility

Synthetically developed and ultra-pure, Syn®-Ake is easily absorbed and exceptionally well tolerated—even by sensitive skin.

4. Instant Results with Long-Term Benefits

The effects of Syn®-Ake can be seen quickly—after just a few applications, the skin appears visibly smoother. With continued use, results become deeper and more enduring.

5. Skin Revitalization

Syn®-Ake enhances overall skin texture, reduces the appearance of pigmentation spots, and promotes a radiant complexion. It supports cell regeneration for a fresh, vibrant look.

Syn®-Ake and Hyaluronic Acid – A Duo with Deep-Acting Power

A single active ingredient is rarely enough to counteract skin aging in a truly holistic way. Ingredients like Syn®-Ake reach their full potential when integrated into a carefully designed formulation. One of the most effective pairings is with low-molecular-weight hyaluronic acid - a proven essential in modern skincare.

Hyaluronic acid has the remarkable ability to bind large amounts of water. It deeply hydrates the skin, plumps it from within, and supports cellular regeneration. Combined with the muscle-relaxing properties of Syn®-Ake, this creates a synergistic effect: while Syn®-Ake helps reduce the formation of new wrinkles, hyaluronic acid improves skin texture, elasticity, and firmness. Products built on this combination provide a truly comprehensive anti-aging approach.

Hyaluron Lifting Serum by DOC BERGER EFFECT – High-Tech Skincare with Syn®-Ake

Our Hyaluron Lifting Serum is a prime example of modern, science-driven skincare. It combines the muscle-relaxing effect of Syn®-Ake with highly effective hyaluronic acid and a selection of intelligently chosen actives that work together to target deep biological skin rejuvenation and stimulate collagen production.

With its lightweight, fast-absorbing texture, the serum fits seamlessly into any skincare routine—applied morning or evening after cleansing, it delivers both instant and lasting results. Skin is immediately hydrated, appears smoother, and radiates a fresh, healthy glow.

Another key advantage is its skin-friendly formulation: developed according to our Clean Beauty philosophy, it is crafted without potentially irritating ingredients such as alcohol or fragrance, making it perfectly suited even for sensitive skin types.